Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
What is it?
MERS-CoV is the virus that causes Middle East respiratory syndrome (MERS). It is a coronavirus, part of the same family of viruses that causes the common cold and SARS (severe acute respiratory syndrome). MERS is a zoonotic disease, meaning it passes from animals to humans. It’s thought that camels are a major source of infection in people (known as primary cases). Raising camels, eating undercooked camel meat, and drinking raw camel milk or urine are risk factors for the disease in humans. MERS-CoV can also spread from person to person, usually through close contact (known as secondary cases).
Where does it occur?
The disease was first reported in Saudi Arabia in 2012, and most reported cases have been linked to countries in and around the Arabian Peninsula.
According to WHO, at the end of January 2020, a total of 2519 laboratory-conﬁrmed cases of MERS, including 866 associated deaths (case-fatality rate: 34.3%) were reported globally.
The majority of these cases were reported from Saudi Arabia (2121 cases), including 788 related deaths with a case-fatality rate of 37.1%.
In 2015, a large outbreak occurred in South Korea as a result of a single super-spreading event, transmitting the virus to 82 people in three days.
Since 2012, cases have been reported in 27 countries. 12 countries in the Eastern Mediterranean region have reported cases.
Who does it affect?
MERS-CoV can infect people of any age. It causes a severe acute respiratory illness with fever, cough and shortness of breath. Gastrointestinal symptoms can also occur. Around 35-37% of people reported as having MERS have died, many of whom already had an underlying medical condition.
The age group 50–59 years continues to be at highest risk for acquiring infection of primary cases. The age group 30–39 years is most at risk for secondary cases. The number of deaths is higher in the age group 50-59 years for primary cases and 70-79 years for secondary cases.
How do we currently prevent infections?
People are advised to try and prevent getting infected by avoiding undercooked or raw camel products, and by being hygienic, especially around animals.
There is currently no specific antiviral treatment for or vaccine against MERS-CoV.
CEPI has 5 MERS vaccine candidates in its portfolio.